etaracizumab   

GtoPdb Ligand ID: 6596

Synonyms: etaratuzumab | hLM60 | MEDI-522
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Bioactivity Comments
The affinity of the originating monoclonal, Vitaxin® (MEDI-523) was optimised by mutation of the Fc region (specifically isoleucine 332 of the CH2 domain) to generate etaracizumab (MEDI-522) [4], which expresses I332E mutation (Vitaxin-1M in the referenced patent). In the binding assays performed as part of the patent application Vitaxin® had a measured Kd of 3470nM.
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
integrin αVβ3 Hs Antibody Binding 6.3 pKd - 4
pKd 6.3 (Kd 4.58x10-7 M) [4]