catumaxomab   Click here for help

GtoPdb Ligand ID: 7385

Synonyms: L01XC09 | Removab®
Approved drug
catumaxomab is an approved drug (EMA (2009))
Compound class: Antibody
Comment: Catumaxomab belongs to a novel generation of engineered monoclonal antibodies termed trifunctional (or Triomab®) antibodies [1,5-6].

Triomabs are hybrid antibodies that carry different antigen binding domains derived from rat IgG2b and mouse IgG2a monoclonals. One binding site (specified by the mouse IgG2a chain chain) is designed to interact with a specific tumour-associated antigen, in catumaxomab's case EpCAM. The other catumaxomab antigen binding site interacts with CD3e (specified by the rat IgG2b chain) on polyclonal T lymphocytes (effector cells). Finally, the intact Fc region of the Triomab® interacts with Fcγ receptors on accessory cells (monocytes/macrophages, natural killer cells and dendritic cells). This combination of interactions enables the formation of a tri-cell complex composed of tumour cells, T cells and accessory cells and promotes the synchronous activation of a variety of immune effector mechanisms that ultimately mediate an enhanced anti-tumour response.
Bioactivity Comments
We have been unable to find peptide sequences for this antibody, and have not been able to trace publicly available affinity data which substantiates its MMOA. Based on biological data we have tagged CD3E as a primary molecular target of catumaxomab [2-4,7].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD3e Primary target of this compound Hs Antibody Binding - - - 2