GtoPdb Ligand ID: 7983

Synonyms: ACTIMAB® | HuM195 | SGN-33 | SMART M195
Compound class: Antibody
Comment: Lintuzumab is a monoclonal antibody directed against CD33, a surface antigen found on myeloid leukemia cells. A modified version of lintuzumab that is conjugated with the chelator satetraxetan to facilitate actinium (225Ac) radiolabelling (a radioimmunotherapeutic) has been developed (see Patent US6670456 [4] and IMGT/mAb-db ID 936). 225Ac emits α particles and is used as these cause less nonspecific cytotoxicity than β particles (i.e. decreased killing of bystander cells). 225Ac has been termed a 'nano-generator' as for each decay producing a high-energy α particle, a series of daughter atoms generate additional α particles, effectively amplifying the radioactive dose at the target site. Lintuzumab is a humanized version of the murine anti-CD33 antibody, M195 [2].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD33 Hs Antibody Binding ~10.0 pKd - 2
pKd ~10.0 (Kd ~1x10-10 M) [2]