Synonyms: hMN-14-SN-38 | hMN-14-SN-38 ADC | IMMU 130 | IMMU-130
Compound class:
Antibody
Comment: Labetuzumab govitecan (research code IMMU-130) is an antibody-drug conjugate (ADC) in which the anti-CEACAM5 antibody labetuzumab, is covalently bound to SN-38, the active metabolite of the topoisomerase inhibitor irinotecan (as exemplified in patents [2] and [1]).
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Bioactivity Comments |
Conjugating the drug moeity should have little effect on the binding affinity of the antibody for its target CEACAM5. |
Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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