aducanumab   Click here for help

GtoPdb Ligand ID: 8325

Synonyms: aducanumab-avwa | Aduhelm® | BART | BIIB-037 | BIIB037
Approved drug
aducanumab is an approved drug (FDA (2021))
Compound class: Antibody
Comment: Aducanumab is a fully human IgG1-kappa monoclonal antibody directed against the amyloid beta (Aβ) found in the amyloid plaques in the brain tissue of patients with Alzheimer's disease (AD).
Peptide sequences and structural information about this antibody are available from its IMGT/mAb-DB record. A patent search reveals Biogen Idec's patent submission WO2014089500 [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
amyloid β Primary target of this compound Hs Antibody Binding 9.4 pEC50 - 2
pEC50 9.4 (EC50 4x10-10 M) [2]
Description: Binding to recombinamt human Aβ 1-42