P8 [PMID: 25923432]   Click here for help

GtoPdb Ligand ID: 8345

Comment: This small peptide represents amino acids 67-73 of presenilin 1. The peptide is water soluble [1].
Bioactivity Comments
P8 has been shown to reduce amyloid beta (Aβ) levels in vitro and in the brains of transgenic mice expressing human APP [1]
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
amyloid β Primary target of this compound Hs Inhibitor Binding 8.5 pKd - 1
pKd 8.5 (Kd 3.45x10-9 M) [1]
Description: Assessed using biolayer interferometry measuring the binding of the test peptide to the soluble ectodomain of APP.
Ligand mentioned in the following text fields