fibatuzumab   

GtoPdb Ligand ID: 8925

Synonyms: KB-004 | KB004
Compound class: Antibody
Comment: Fibatuzumab is a humanised monoclonal antibody directed against the ephrin receptor A3 (EPHA3) [6], which is a receptor tyrosine kinase implicated in mediating nervous system development [2,7-8].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST searches of patented peptide sequences using the variable domains of the light and heavy chain sequences of fibatuzumab reveal exact matches with sequences submitted with patent US8664365 B2 [6].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
EPH receptor A3 Hs Antibody Binding >9.0 pKd - 6
pKd >9.0 (Kd <1x10-9 M) [6]
EPH receptor A3 Mm Antibody Binding >9.0 pKd - 6
pKd >9.0 (Kd <1x10-9 M) [6]