onartuzumab

Ligand id: 8966

Name: onartuzumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Patent US7615529 [4] does not provide an affinity value for the interaction between the antibody and its target [4]. We have tagged MET as the primary molecular target based on the information provided in this patent submission and have provided the IC50 value generated from a MET competitive binding assay with biotinylated HGF, reported in US20050227324 [2].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Hs Antibody Binding 8.4 pIC50 - 2,4
pIC50 8.4 (IC50 4.3x10-9 M) [2,4]