ligelizumab   Click here for help

GtoPdb Ligand ID: 8997

Synonyms: CL-2C | NVP-QGE031 | QGE031
Immunopharmacology Ligand
Compound class: Antibody
Comment: Ligelizumab is a humanized, investigational high-affinity anti-IgE monoclonal antibody with anti-inflammatory potential [1], with improved pharmacokinetics and clinical effects compared to omalizumab.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide sequence analysis reveals identical matches with antibody sequences claimed in patent US7531169 B2, where it is the clone designated as CL-2C [3].
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
immunoglobulin heavy constant epsilon Primary target of this compound Hs Antibody Binding 9.9 – 11.8 pKd - 1,3
pKd 9.9 – 11.8 (Kd 1.39x10-10 – 1.47x10-12 M) [1,3]
Description: In vitro binding affinity