MM-151   Click here for help

GtoPdb Ligand ID: 9125

Compound class: Antibody
Comment: MM-151 is a mixture of three fully human IgG1 monoclonal antibodies, each of which targets a distinct (and nonoverlapping) epitope on the extra-cellular domain of the EGFR [2]. This can be termed an oligoclonal agent. It was designed to target EGFRs with treatment-induced (acquired) resistance mutations that develop in cancer patients treated with the approved anti-EGFR monoclonals cetuximab or panitumumab. Development of the three antibody components is reported in [1].
Bioactivity Comments
We have tagged the EGFR as the primary molecular target of MM-151 based on preclinical results published in [2].
MM-151 antagonises high-affinity EGFR ligands more potently than cetuximab [2], and In cell viability studies, exhibits effective antiproliferative activity.
The P1X antibody component of MM-151 has an EGFR dissociation Kd of 0.071nM, the Kd for P2X is 0.3nM and for P3X is 0.011nM [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
epidermal growth factor receptor Primary target of this compound Hs Antibody Binding - - - 1-2