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Synonyms: ATN-103 | PF-5230896
Compound class:
Antibody
Comment: Ozoralizumab is a trivalent albumin-binding nanobody that binds to and neutralises circulating TNFα. This biologic agent is being investigated for anti-inflammatory potential. The peptide sequence for ozoralizumab submitted in its WHO INN record is identical to SEQ ID NO: 96 (TNF30) in patent US8703131 [1], and identifies the albumin nanobody as ALB8. The patent claims a trivalent construct of TNF30-linker-ALB8-linker-TNF30.
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| Bioactivity Comments |
| Ozoralizumab binds serum albumin, in addition to TNFα, an action that increases its in vivo half-life [2]. |
| Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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