GtoPdb Ligand ID: 9847

Synonyms: HuZAF
Compound class: Antibody
Comment: Fontolizumab (HuZAF) is a humanized anti-IFNγ mAb designed for the treatment of auto-immune diseases like Crohn's disease. This antibody is claimed in patent US6329511 [4]. It is one of the novel agents for immune-mediated inflammatory diseases discussed in Baker et al. (2018) [1].
Bioactivity Comments
Fontolizumab neutralises the proinflammatory activity of IFNγ, as measured by antibody-mediated reduction in IFNγ-induced upregulation of MHC II expression by Hs294T melanoma cells [4].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IFN-γ Hs Antibody Binding - - - 4