ipafricept

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ipafricept

GtoPdb Ligand ID: 10325

Synonyms: FZD8-Fc | OMP-54F28 | OMP54F28

Compound class: Peptide or derivative

Comment: Ipafricept (OMP-54F28) is a fusion protein that fuses the FZD₈ cysteine-rich domain to human IGHG1 Fc fragment [1]. It acts as a soluble decoy receptor for WNT ligands, and exhibits antitumour efficacy in vivo. Produced by OncoMed Pharmaceuticals.

Summary
Biological activity
Clinical data
References

No information available.

No information available.

Summary of Clinical Use
OMP-54F28 has completed Phase 1 evaluation in subjects with various types of solid tumours. First-in-human results were published in 2017 [2]. Click here to link to ClinicalTrials.gov's full list of OMP-54F28 trials.

Summary of Clinical Use

OMP-54F28 has completed Phase 1 evaluation in subjects with various types of solid tumours. First-in-human results were published in 2017 [2]. Click here to link to ClinicalTrials.gov's full list of OMP-54F28 trials.