envafolimab   Click here for help

GtoPdb Ligand ID: 10492

Synonyms: KN-035 | KN035
Immunopharmacology Ligand
Compound class: Antibody
Comment: Envafolimab (KN035) is a chimeric (human/camelid) anti-PD-L1 nanobody that acts as an immune checkpoint inhibitor, and which is being developed by Alphamab Co [1]. Structurally it is a VH-Fc dimer, and does not contain variable light (VL) domains. It therefore has a reduced molecular size and offers more favourable physico-chemical properties than full-size monoclonal antibodies. X-ray crystal structures show that KN035 binds to the same surface on PD-L1 where the ligand interacts with its cognate receptor PD-1 (programmed death protein 1).
The peptide sequence of envafolimab's heavy chain returned no matches with patented peptide sequences in a Protein: BLAST search in September 2019.
No information available.
Summary of Clinical Use Click here for help
Envafolimab (KN035) has advanced to Phase 3 clinical evaluation (in combination with gemcitabine and oxaliplatin chemotherapy) in patients with biliary tract neoplasms and is in earlier phase trials in solid tumours of other tissue origin. Click here to link to ClinicalTrials.gov's full list of KN035 studies.