lanreotide   Click here for help

GtoPdb Ligand ID: 2031

Synonyms: BIM 23014 | DC 13-116 | lanreotide acetate | Somatuline®
Approved drug
lanreotide is an approved drug (UK (2001), FDA (2007))
Comment: Lanreotide is a synthetic analogue of somatostatin. The compound is represented by a PubChem entry (linked to above) without specified stereochemistry, while ChEMBL represents lantreotide with the entry CHEMBL1201185.
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2D Structure
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Canonical SMILES NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C(CSSCC(NC(=O)C(NC1=O)C(C)C)C(=O)NC(C(=O)N)C(O)C)NC(=O)C(Cc1ccc2c(c1)cccc2)N)Cc1c[nH]c2c1cccc2
Isomeric SMILES NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C(CSSCC(NC(=O)C(NC1=O)C(C)C)C(=O)NC(C(=O)N)C(O)C)NC(=O)C(Cc1ccc2c(c1)cccc2)N)Cc1c[nH]c2c1cccc2
InChI InChI=1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)
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Summary of Clinical Use Click here for help
Used to treat acromegaly, where other treatments have been unsucessful. May also be used to treat symptoms associated with neuroendocrine tumours such as TSH-secreting thyrotrophic adenomas.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Endogenous somatostatin (via the somatostatin receptors) blocks the release of several other hormones, including growth hormone, thyroid-stimulating hormone (TSH), insulin and glucagon. Lanreotide mimics this effect. In acromegalic patients this drug reduces growth hormone and IGF-1 levels.
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