Ligand id: 2644

Name: tretinoin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 37.3
Molecular weight 300.21
XLogP 6.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Retinoids are used in the treatment of various skin disorders, including acne, UV damage and keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin is also used as a differentiating agent and anticancer drug in the treatment of acute promyelocytic leukemia.
Mechanism Of Action and Pharmacodynamic Effects
The effectiveness of tretinoin in treating indicated skin disorders appears to be due to its ability to modify abnormal follicular keratinization. The mechanism of effectiveness in treating acute promyelocytic leukemia is not fully understood.
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