colfosceril palmitate   

GtoPdb Ligand ID: 2799

Synonyms: DPPC | Exosurf Neonatal®
colfosceril palmitate is an approved drug
Comment: Colfosceril palmitate is a pulmonary surfactant.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 40
Topological polar surface area 118.17
Molecular weight 734.57
XLogP 13.85
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Canonical SMILES CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COP(=O)(OCC[N+](C)(C)C)O
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(=O)(OCC[N+](C)(C)C)O
InChI InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/p+1/t38-/m1/s1
InChI Key KILNVBDSWZSGLL-KXQOOQHDSA-O
No information available.
Summary of Clinical Use
Has been used clinically to treat neonatal respiratory distress syndrome. It appears to be approved in very few countries (Argentina and Bulgaria, according to Drugs.com's international drugs list).