colfosceril palmitate   Click here for help

GtoPdb Ligand ID: 2799

Synonyms: DPPC | Exosurf Neonatal®
Approved drug
colfosceril palmitate is an approved drug
Compound class: Metabolite
Comment: Colfosceril palmitate is a pulmonary surfactant.
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 40
Topological polar surface area 118.17
Molecular weight 734.57
XLogP 13.85
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COP(=O)(OCC[N+](C)(C)C)O
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(=O)(OCC[N+](C)(C)C)O
InChI InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/p+1/t38-/m1/s1
InChI Key KILNVBDSWZSGLL-KXQOOQHDSA-O
No information available.
Summary of Clinical Use Click here for help
Has been used clinically to treat neonatal respiratory distress syndrome. It appears to be approved in very few countries (Argentina and Bulgaria, according to Drugs.com's international drugs list).