testosterone   Click here for help

GtoPdb Ligand ID: 2858

Synonyms: Androderm® | Delatestryl®
Approved drug PDB Ligand
testosterone is an approved drug (FDA (1953))
Compound class: Metabolite
Comment: Testosterone is the principal male sex hormone and an anabolic steroid.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: testosterone

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 288.21
XLogP 3.63
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES O=C1CCC2(C(=C1)CCC1C2CCC2(C1CCC2O)C)C
Isomeric SMILES O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C)C
InChI InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
InChI Key MUMGGOZAMZWBJJ-DYKIIFRCSA-N
No information available.
Summary of Clinical Use Click here for help
Uses in males include management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Used in females include palliative treatment of androgen-responsive, advanced inoperable metastasis carcinoma of the breast in women who are 1-5 years postmenopausal, and in combination with estrogens to manage vasomotor symptoms associated with the menopause in women who do not repond to estrogen treatment alone.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Androgen receptor agonist. Testosterone is also converted to estradiol in thereby leading to the activation of estogen receptors.
External links Click here for help