Ligand id: 4214

Name: heparin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 35
Hydrogen bond donors 14
Rotatable bonds 19
Topological polar surface area 588.61
Molecular weight 1039.04
XLogP -11.46
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Heparin is used clinically as an anti-coagulant.
Mechanism Of Action and Pharmacodynamic Effects
Heparin binds reversibly to antithrombin III (ATIII) and leads to almost instantaneous inactivation of coagulation factors IIa and Xa, thereby reducing clotting function.