Abbreviated name: IGF-1
Synonyms: CEP-151 | mechano growth factor (MGF) | myotrophin
insulin-like growth factor 1 is an approved drug (FDA (2005))
Compound class:
Endogenous peptide in human, mouse or rat
Comment: The recombinant form of human IGF-1 is an approved drug, mecasermin.
Species: Human
![]() View more information in the IUPHAR Pharmacology Education Project: insulin-like growth factor 1 |
No information available. |
Summary of Clinical Use ![]() |
In its recombinant form as the approved drug mecasermin, IGF1 is used to improve growth in pediatric patients with primary insulin-like growth factor 1 deficiency. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Mecasermin acts through the type 1 IGF-1 receptor and mimics the effects of endogenous IGF-1 on the growth of bones and muscles. |