insulin-like growth factor 1   Click here for help

GtoPdb Ligand ID: 4971

Abbreviated name: IGF-1
Synonyms: CEP-151 | mechano growth factor (MGF) | myotrophin
Approved drug
insulin-like growth factor 1 is an approved drug (FDA (2005))
Comment: The recombinant form of human IGF-1 is an approved drug, mecasermin.
Species: Human
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Summary of Clinical Use Click here for help
In its recombinant form as the approved drug mecasermin, IGF1 is used to improve growth in pediatric patients with primary insulin-like growth factor 1 deficiency.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mecasermin acts through the type 1 IGF-1 receptor and mimics the effects of endogenous IGF-1 on the growth of bones and muscles.