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Ligand id: 6881
View more information in the IUPHAR Pharmacology Education Project: tocilizumab
|No information available.|
|Summary of Clinical Use|
|tocilizumab had been approved in Japan in 2005 as a treament for giant lymph node hyperplasia (Castleman's disease) , before being granted EMA and FDA approvals for use as a treatment for rheumatoid arthritis [1,5] and systemic and polyarticular juvenile idiopathic arthritis .
In May 2017 tocilizumab became the first FDA approved drug for the treatment of adults with giant cell arteritis.
Phase 3 clinical trials for immune conditions including ankylosing spondylitis, hand osteoarthritis, systemic sclerosis and primary Sjögren's syndrome (pSS) are ongoing. Tocilizumab was initally used off-label to manage severe or life-threatening cytokine release syndrome (CRS), which is a serious, and potentially life-threatening side effect of CAR T-cell therapy. In September 2017, the FDA extended tocilizumab approval to include treatment of CAR T-cell therapy-induced CRS. It was approved particularly to manage CRS in patients ≥2 years of age receiving tisagenlecleucel (Kymriah®,CTL019), the first CAR T-cell therapy approved for relapsed and refractory B-cell ALL.
|Mechanism Of Action and Pharmacodynamic Effects|
|Binds to soluble and membrane-bound IL-6 receptors to inhibit IL-6 signalling via these receptors [3-4], thereby reducing the effect of the elevated/deregulated circulating IL-6 which is a hallmark of the targeted chronic autoimmume diseases.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)