muromonab-CD3   Click here for help

GtoPdb Ligand ID: 6889

Synonyms: L04AA02 | OKT-3 | Orthoclone Okt3®
Approved drug Immunopharmacology Ligand
muromonab-CD3 is an approved drug (FDA (1992))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
No information available.
Summary of Clinical Use Click here for help
Used to prevent renal, cardiac and hepatic allograft rejection. Due to reduced demand and use in the US, the manufacturer has withdrawn muromonab-CD3 from the US market.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The antibody binds to the T-cell surface glycoprotein CD3 and appears to kill these cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
External links Click here for help