ethynodiol diacetate   Click here for help

GtoPdb Ligand ID: 7072

Synonyms: Continuin® | Femulen® | SC-11800
Approved drug
ethynodiol diacetate is an approved drug
Comment: This compound is a progestin.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 52.6
Molecular weight 384.23
XLogP 5
No. Lipinski's rules broken 0
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Isomeric SMILES C#C[C@@]1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=C[C@H](CC[C@H]12)OC(=O)C)OC(=O)C
InChI InChI=1S/C24H32O4/c1-5-24(28-16(3)26)13-11-22-21-8-6-17-14-18(27-15(2)25)7-9-19(17)20(21)10-12-23(22,24)4/h1,14,18-22H,6-13H2,2-4H3/t18-,19-,20+,21+,22-,23-,24-/m0/s1
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Summary of Clinical Use Click here for help
This drug is used alone or in combination with estrogens in oral contraceptive formulations. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Artificial maintainence of high levels of circulating progestin feeds back to reduce the frequency of gonadotrophin-releasing hormone (GnRH) pulses which blunts the pre-ovulatory lutenising hormone (LH) surge, and the ovaries cease cyclic ovulation.