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Synonyms: asparaginase | Elspar® | L-asparaginase | L-asparagine amidohydrolase
crisantaspase is an approved drug (FDA (no history prior to 2011))
Compound class:
Peptide or derivative
Comment: Crisantaspase is a chemotherapy agent. The asparaginase enzyme can be isolated from Erwinia chrysanthemi or Escherichia coli. The two forms have different immunogenicity profiles. The amino acid sequence shown here is for the Erwina isoform, crisantaspase.
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| No information available. |
Summary of Clinical Use  |
| Used to treat acute lymphoblastic leukemia (ALL) and some mast cells tumours [1]. The European Medicines Agency have delivered positive opinions on the use of several asparaginase formulations for the treatment of rare diseases. For more information regarding current clinical trials testing crisantaspase, visit www.clinicaltrials.gov. |
| Mechanism Of Action and Pharmacodynamic Effects |
| Some cancer cells are unable to synthesise the amino acid asparagine. Use of asparaginase effectively starves tumour cells of asparagine leading to cell death, whilst normal cells continue to produce their own asparagine and survive. |
| External links |
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For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com |
