AlprolixTM   Click here for help

GtoPdb Ligand ID: 7373

Approved drug
AlprolixTM is an approved drug (FDA (2014))
Comment: AlprolixTM is a recombinant fusion protein combining the peptide for coagulation factor IX with an antibody Fc domain. The presence of the Fc domain increases protein half-life and extends the drug's therapeutic window.
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Summary of Clinical Use Click here for help
Designated as an orphan drug by the US FDA, this drug may be used as a prophylactic to reduce bleeding episodes in patients suffering from Hemophilia B. The benefit of this drug is its extended half-life compared to previous treatments, meaning that patients require less frequent injections.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Replaces the factor IX missing in hemophilia B patients, to restore clotting function and reduce pathological bleeding events.