secukinumab   Click here for help

GtoPdb Ligand ID: 8078

Synonyms: AIN 457 | AIN457 | Cosentyx® | NVP-AIN457
Approved drug Immunopharmacology Ligand
secukinumab is an approved drug (Japan (2014), FDA and EMA (2015))
Compound class: Antibody
Comment: Peptide sequences for this antibody are available from its IMGT/mAb-DB entry.
This antibody is the subject of patent US7807155 [2].
No information available.
Summary of Clinical Use Click here for help
Secukinumab is approved by the US FDA for the treatment of plaque psoriasis.
Secukinumab also met its clinical endpoints in Phase 2I clinical trial for ankylosing spondylitis (NCT01649375) [1], and was FDA approved for this indication and psoriatic arthritis [7-8] in January 2016.
The antibody is also in Phase 2 clinical trial for multiple sclerosis (NCT01874340) based on results from experiments in an animal model of the disease (experimental autoimmune encephalomyelitis, EAE) and in vitro human cell assays [3].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Secukinumab targets proinflammatory interleukin (IL)-17A [5] which is released by T helper 17 cells [11], and is a validated molecular target for the treatment of chronic immune diseases [10]. Antibody neutralisation of circulating IL-17A reduces symptoms in autoimmune diseases such as plaque psoriasis [6,9], rheumatoid arthritis (note that clinical trial results have not shown significant improvement over placebo [4]), and chronic noninfectious uveitis.
External links Click here for help