anti-ILT7 antibody   Click here for help

GtoPdb Ligand ID: 9124

Compound class: Antibody
Comment: This anti-ILT7 antibody is claimed in patent US8084585 [1], in which it is isolated from hybridoma ILT7#11. It was developed as a novel therapeutic for the treatment of autoimmune condtions. Note that ILT7 is interchangeable with the official gene symbol LILRA4.
No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Neutralising LILRA4 is predicted to directly inhibit the activity and IFNα producing capacity of plasmacytoid dendritic cells (pDCs). Figure 12 in US8084585 [1] shows that anti-ILT7 antibody induces complement dependent cytotoxicity (CDC) against targeted cells.