lymphotoxin-α   Click here for help

GtoPdb Ligand ID: 5064

Abbreviated name: TNFSF1
Synonyms: LTα | TNFβ
Immunopharmacology Ligand
Comment: LTA (TNFβ) is a pro-inflammarory cytokine mediating a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is required during embryonic development of lymphoid organs.
Species: Human
Immunopharmacology Comments
LTA (TNFβ) is a lymphocyte produced cytokine of the tumor necrosis factor family. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, and is required during embryonic development of lymphoid organs. Genetic variants are associated with non-Hodgkin's lymphoma, and psoriatic arthritis.
Immunopharmacology Disease
Disease X-Refs Comment References
Lymphoma, non-hodgkin, familial Disease Ontology: DOID:0060060
OMIM: 605027
Approved therapy for this indication.
Psoriatic arthritis Disease Ontology: DOID:9008
Approved therapy for PsA.