CXCL6   Click here for help

GtoPdb Ligand ID: 820

Immunopharmacology Ligand
Comment: Human CXCL6 is most closely related to CXCL5.
Species: Human
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Immunopharmacology Comments
CXCL6 is upregulated by IL-1β and downregulated by IFN-γ. It is a chemoattract for neutrophils and exhibits proangiogenic properties. It has actions in physiologic and pathologic processes.
Immunopharmacology Disease
Disease X-Refs Comment References
Scleroderma Disease Ontology: DOID:419
Serum CXCL6 levels are reported to positively correlate with the severity of dermal and pulmonary fibrosis and vascular symptoms in patients with systemic sclerosis (scleroderma). 1