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Synonyms: fractalkine | neurotactin
Compound class:
Endogenous peptide in human, mouse or rat
Comment: This is the only member of the CX3C chemokine family [1].
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| Soluble CX3CL1 is a chemoattractant for T cells and monocytes and the membrane bound ligand is involved in leukocyte-endothelial adhesion via its mucin-like domain. It is the ligand for chemokine receptor CX3CR1 [3]. The CX3CL1/CX3CR1 axis also plays a role in microglial cell migration [5]. Eisai is developing quetmolimab (E6011 ; KANAb 001), a first-in-class humanised anti-CX3CL1 monoclonal antibody for immunomodulatory potential in the treatment of rheumatoid arthritis [7] (max Phase 2 e.g. NCT02960490), Crohn's disease (Phase 1/2 NCT02039063) and primary biliary cholangitis (Phase 2 NCT03092765) [4,6-7]. |
