GtoPdb Ligand ID: 9517

Synonyms: TACI-Fc | TACI-Ig
Comment: Atacicept is a recombinant fusion protein designed to inhibit B cells, being investigated as an intervention in autoimmune diseases [1]. Mechanistically atacicept neutralises the function of two important B-cell activating factors, BAFF (BLyS) and APRIL. Structurally atacicept contains the BLyS/APRIL-binding extracellular portion of the TACI receptor fused to a modified Fc from human IgG1 [3]. One of the important functions of these two factors in autoimmune disease is their ability to induce proliferation of plasma cells and thus increase Ig production, in paticular the production of destructive anti-self antibodies.
Peptide sequences and structural information for this peptide are available from its IMGT/mAb-DB entry. The peptide sequence for atacicept is claimed in patent WO2002094852 [4].
Immunopharmacology Comments
A fusion protein which neutralises BAFF and APRIL signalling via the B cell receptor TACI, and is being investigated as a therapeutic for autoimmunce diseases.
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Atacicept is in clinical development for the treatment of RA.
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
Atacicept is in clinical development for the treatment of SLE. 1