IgE heavy chain   Click here for help

GtoPdb Ligand ID: 9557

Immunopharmacology Ligand
Comment: This entity is in the GtoPHARMACOLOGYdb and GtoImmuPdb as both a ligand (of the Fcε receptors) and as a target (target of anti-IgE monoclonal antibodies- see IGHE).
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Immunopharmacology Comments
This protein forms the Fc or constant domain of IgE antibodies. This domain interacts with Fcε receptors to induce an immune response but is not involved in antigen recognition. Fc ε is the molecular target of the anti-IgE monoclonal omalizumab that is an approved asthma therapeutic.
Immunopharmacology Disease
Disease X-Refs Comment References
Asthma Disease Ontology: DOID:2841
OMIM: 600807
Target of approved anti-asthmatic biological omalizumab.