tregalizumab   Click here for help

GtoPdb Ligand ID: 9864

Synonyms: BT-061 | hB-F5
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tregalizumab (BT-061) is an anti-CD4 monoclonal antibody that was developed by Biotest Ag as a potential anti-rheumatoid arthritis therapy [4].
Immunopharmacology Comments
Tregalizumab was designed to selectively activate Treg cells and boost their function to mediate an increase in their immunosuppressive activity [1-2].
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Tregalizumab failed to show clinical efficacy in Phase 2 trial (NCT01999192), and development was discontinued. 3