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Synonyms: annexin I, Ac2-26 | annexin-derived peptide | ANXA1-derived peptide
Compound class: Endogenous peptide in human, mouse or rat
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U. (2004)
An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.
J Immunol, 172 (12): 7669-76. [PMID:15187149]
2. Gavins FN, Yona S, Kamal AM, Flower RJ, Perretti M. (2003)
Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms.
Blood, 101 (10): 4140-7. [PMID:12560218]
3. Hayhoe RP, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M. (2006)
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.
Blood, 107 (5): 2123-30. [PMID:16278303]
4. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN. (2002)
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.
Nat Med, 8 (11): 1296-302. [PMID:12368905]
5. Walther A, Riehemann K, Gerke V. (2000)
A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR.
Mol Cell, 5 (5): 831-40. [PMID:10882119]