GABA   Click here for help

GtoPdb Ligand ID: 1067

Synonyms: γ-amino butyric acid | 4-aminobutyric acid | gamma-aminobutyric acid
PDB Ligand
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: gaba

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 63.32
Molecular weight 103.06
XLogP -0.67
No. Lipinski's rules broken 0
Click here for help
InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
1. Anderson CM, Howard A, Walters JR, Ganapathy V, Thwaites DT. (2009)
Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl(-)-dependent TauT (SLC6A6).
J Physiol (Lond.), 587 (Pt 4): 731-44. [PMID:19074966]
2. De Saint Jan D, David-Watine B, Korn H, Bregestovski P. (2001)
Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA.
J Physiol (Lond.), 535 (Pt 3): 741-55. [PMID:11559772]
3. Froestl W, Mickel SJ. (1997)
Chemistry of GABAB modulators.  In  The GABA Receptors
Edited by Enna SJ, Bowery NG (Humana Press) 271-296. [ISBN:0896034585]
4. Hirst WD, Babbs AJ, Green A, Minton JA, Shaw TE, Wise A, Rice SQ, Pangalos MN, Price GW. (2003)
Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.
Biochem Pharmacol, 65 (7): 1103-13. [PMID:12663046]
5. Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W et al.. (1997)
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Nature, 386 (6622): 239-46. [PMID:9069281]
6. McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM. (1997)
Identification and characterization of the vesicular GABA transporter.
Nature, 389 (6653): 870-6. [PMID:9349821]
7. Schmieden V, Kuhse J, Betz H. (1993)
Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.
Science, 262 (5131): 256-8. [PMID:8211147]
8. Thwaites DT, Anderson CM. (2011)
The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.
Br J Pharmacol, 164 (7): 1802-16. [PMID:21501141]
9. Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ et al.. (2000)
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Br J Pharmacol, 131 (6): 1050-4. [PMID:11082110]