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Compound class: Peptide or derivative
Comment: Synthetic analogue of human GHRH
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Varga JL, Schally AV, Csernus VJ, Zarándi M, Halmos G, Groot K, Rékási Z. (1999)
Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Proc Natl Acad Sci USA, 96 (2): 692-7. [PMID:9892695]
2. Varga JL, Schally AV, Horvath JE, Kovacs M, Halmos G, Groot K, Toller GL, Rekasi Z, Zarandi M. (2004)
Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Proc Natl Acad Sci USA, 101 (6): 1708-13. [PMID:14755056]
3. Zarandi M, Horvath JE, Halmos G, Pinski J, Nagy A, Groot K, Rekasi Z, Schally AV. (1994)
Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Proc Natl Acad Sci USA, 91 (25): 12298-302. [PMID:7991622]
4. Zarandi M, Kovacs M, Horvath JE, Toth K, Halmos G, Groot K, Nagy A, Kele Z, Schally AV. (1997)
Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Peptides, 18: 423-430. [PMID:9145431]