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Synonyms: (3,5)-difluoro Phe-ψ-Ala
Compound class: Peptide or derivative
Comment: A dipeptide probe that can be radiolabelled with the [19F] isotope to study peptide transporters . Alternate probes were tested in this study by Arakawa et al. (2020). The L-phenylalanyl-ψ[CS-N]-L-alanine dipeptide backbone is resistant to cleavage by peptidases.
1. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T et al.. (2020)
Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.
Int J Pharm, 586: 119575. [PMID:32622809]