faricimab   Click here for help

GtoPdb Ligand ID: 11420

Synonyms: faricimab-svoa | RG-7716 | RG7716 | RO-6867461 | RO6867461 | Vabysmo®
Approved drug
faricimab is an approved drug (EMA & FDA (2022))
Compound class: Antibody
Comment: Faricimab is a bispecific monoclonal antibody that simultaneously binds to angiopoietin 2 (Ang2) and vascular endothelial growth factor A (VEGF-A) [3-4]. It is an angiogenesis inhibitor. The FcRn and FcγR binding sites of faricimab have been modified to disable its Fc‐mediated effector functions. Faricimab does not bind to Ang1 [4].
1. Foxton RH, Uhles S, Grüner S, Revelant F, Ullmer C. (2019)
Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization.
EMBO Mol Med, 11 (5). [PMID:31040126]
2. Khanani AM, Patel SS, Ferrone PJ, Osborne A, Sahni J, Grzeschik S, Basu K, Ehrlich JS, Haskova Z, Dugel PU. (2020)
Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The STAIRWAY Phase 2 Randomized Clinical Trial.
JAMA Ophthalmol, 138 (9): 964-972. [PMID:32729897]
3. Nicolò M, Ferro Desideri L, Vagge A, Traverso CE. (2021)
Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases.
Expert Opin Investig Drugs, 30 (3): 193-200. [PMID:33471572]
4. Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Cheung CM, Bo Tun SB, Wey YS, Iwata D, Dostalek M, Moelleken J et al.. (2016)
Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.
EMBO Mol Med, 8 (11): 1265-1288. [PMID:27742718]
5. Sahni J, Patel SS, Dugel PU, Khanani AM, Jhaveri CD, Wykoff CC, Hershberger VS, Pauly-Evers M, Sadikhov S, Szczesny P et al.. (2019)
Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial.
Ophthalmology, 126 (8): 1155-1170. [PMID:30905643]