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Compound class:
Peptide or derivative
Comment: SI5α-b is a small (7 amino acids) peptide that binds to the receptor-binding domain (RBD; specifically residues Y453, Q498 and N501) of the SARS-CoV-2 spike protein and thereby blocks its interaction with angiotensin-converting enzyme 2 (ACE2) [1]. It exhibits antiviral activity in vitro, in an assay of Vero E6 cell infection by the pangolin coronavirus virus GX_P2V.
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| References |
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1. Pei P, Qin H, Chen J, Wang F, He C, He S, Hong B, Liu K, Qiao R, Fan H et al.. (2021)
Computational design of ultrashort peptide inhibitors of the receptor-binding domain of the SARS-CoV-2 S protein. Brief Bioinform, 22 (6). [PMID:34180984] |
