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Synonyms: gonadoliberin II | gonadoliberin-2 | gonadotropin-releasing hormone II | LH-RH II | luliberin II | luteinizing hormone-releasing hormone II
Compound class: Endogenous peptide in human, mouse or rat
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Fister S, Günthert AR, Aicher B, Paulini KW, Emons G, Gründker C. (2009)
GnRH-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells via activation of stress-induced MAPKs p38 and JNK and proapoptotic protein Bax.
Cancer Res, 69 (16): 6473-81. [PMID:19638591]
2. Lu ZL, Coetsee M, White CD, Millar RP. (2007)
Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.
J Biol Chem, 282 (24): 17921-9. [PMID:17452338]
3. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R et al.. (2001)
A novel mammalian receptor for the evolutionarily conserved type II GnRH.
Proc Natl Acad Sci USA, 98 (17): 9636-41. [PMID:11493674]
4. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. (2004)
Gonadotropin-releasing hormone receptors.
Endocr Rev, 25 (2): 235-75. [PMID:15082521]
5. Stewart AJ, Sellar R, Wilson DJ, Millar RP, Lu ZL. (2008)
Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor.
Mol Pharmacol, 73 (1): 75-81. [PMID:17942747]