efmarodocokin alfa   Click here for help

GtoPdb Ligand ID: 12212

Synonyms: IL-22Fc | RG 7880 | RG7880 | UTTR1147A
Compound class: Antibody
Comment: Efmarodocokin alfa is a recombinant human IL-22-Fc IgG4 fusion protein that acts as an agonist of the heterodimeric Interleukin-22α1/10β receptor which is expressed by epithelial cells. It activates the IL-22 signaling pathway without inducing systemic inflammation or causing immunosuppression. Efmarodocokin alfa was developed for potential to treat infectious or inflammatory diseases [2]. The most advanced investigation of its clinical utility has been of its potential to induce repair of the intestinal epithelial damage that is caused by inflammatory bowel diseases [1].
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1. Rothenberg ME, Wang Y, Lekkerkerker A, Danilenko DM, Maciuca R, Erickson R, Herman A, Stefanich E, Lu TT. (2019)
Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury.
Clin Pharmacol Ther, 105 (1): 177-189. [PMID:29952004]
2. Stefanich EG, Rae J, Sukumaran S, Lutman J, Lekkerkerker A, Ouyang W, Wang X, Lee D, Danilenko DM, Diehl L et al.. (2018)
Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases.
Biochem Pharmacol, 152: 224-235. [PMID:29608910]