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Synonyms: [Tic22]26RFa(20-26) | analog 28 [PMID: 34299587]
Compound class:
Peptide or derivative
Comment: LV-2211 is a synthetic 26RFa(20-26) peptide analogue in which the sidechain of the phenylalanine residue at position 22 (F22) is modified with 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) [1]. It is a 5-fold more potent agonist than 26RFa(20-26).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Lefranc B, Alim K, Neveu C, Le Marec O, Dubessy C, Boutin JA, Chuquet J, Vaudry D, Prévost G, Picot M et al.. (2021)
Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study. Molecules, 26 (14). DOI: 10.3390/molecules26144312 [PMID:34299587] |
