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Synonyms: RM-2 | RM2
Compound class:
Peptide or derivative
Comment: [D-Phe6, Stat13, Leu14}Bn(6-14) is a BB2 receptor antagonist [1]. It can be coupled to the chelator DOTA, to render a presursor that can be radiolabelled with Gallium-68 or Indium-111 as tracers for clinical SPECT and PET studies.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Mansi R, Wang X, Forrer F, Waser B, Cescato R, Graham K, Borkowski S, Reubi JC, Maecke HR. (2011)
Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours. Eur J Nucl Med Mol Imaging, 38 (1): 97-107. [PMID:20717822] |
