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Synonyms: Tau-scoloptoxin04-Sm1a
Compound class:
Peptide or derivative
Comment: RhTx is a 27-amino-acid peptide from the venom of the Chinese red-headed centipede. It activates the nociceptor TRPV1, which evokes an acute pain response [1-2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Geron M, Hazan A, Priel A. (2017)
Animal Toxins Providing Insights into TRPV1 Activation Mechanism. Toxins (Basel), 9 (10). [PMID:29035314] |
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2. Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K et al.. (2015)
A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Nat Commun, 6: 8297. [PMID:26420335] |
