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Compound class:
Endogenous peptide in human, mouse or rat
Comment: Netrin 1 is a 604 amino acid peptide. Structurally it contains laminin EGF-like domains, a netrin domain, and a C terminal domain that acts as a cell attachment site. In normal cells netrins are involved in regulating cell guidance, particularly during embryonic development. Netrin 1 is overexpressed in some cancers, and has been associated with tumourigenesis. Experimental evidence suggests that netrin 1 promotes epithelial-to-mesenchymal transition (EMT) and metastasis [2]. Conversely, disrupting netrin 1 (expression or function) has anti-tumour effects [1-2].
Receptors for netrin 1 include DCC netrin 1 receptor (DCC) and unc-5 netrin receptor B (UNC5B); unliganded these receptors promote apoptosis, but in the presence of netrin 1 they induce an EMT.
Species: Human
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| References |
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1. Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L et al.. (2023)
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. Nature, 620 (7973): 409-416. [PMID:37532934] |
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2. Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A et al.. (2023)
Pharmacological targeting of netrin-1 inhibits EMT in cancer. Nature, 620 (7973): 402-408. [PMID:37532929] |
