MCH (salmon)   Click here for help

GtoPdb Ligand ID: 1301

Synonyms: salmon melanin-concentrating hormone
Compound class: Peptide
Click here for help
2D Structure
Click here for help
Click here for structure editor
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES CSCCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)C(C)C)CCC(=O)O)Cc1c[nH]c2c1cccc2)CS)CCCN=C(N)N)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N)C(C)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(O)C)NC(=O)C(CC(=O)O)N)CCSC)CCCN=C(N)N)CS
Isomeric SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)C(C)C
InChI InChI=1S/C89H141N27O24S4/c1-43(2)67(112-76(129)57(29-35-144-9)105-79(132)61(41-141)110-72(125)54(19-13-31-98-88(93)94)103-73(126)56(28-34-143-8)106-84(137)70(46(7)117)115-71(124)51(90)38-66(122)123)82(135)101-40-64(119)102-53(18-12-30-97-87(91)92)74(127)113-68(44(3)4)83(136)109-59(36-47-22-24-49(118)25-23-47)77(130)107-58(20-14-32-99-89(95)96)85(138)116-33-15-21-63(116)81(134)111-62(42-142)80(133)108-60(37-48-39-100-52-17-11-10-16-50(48)52)78(131)104-55(26-27-65(120)121)75(128)114-69(45(5)6)86(139)140/h10-11,16-17,22-25,39,43-46,51,53-63,67-70,100,117-118,141-142H,12-15,18-21,26-38,40-42,90H2,1-9H3,(H,101,135)(H,102,119)(H,103,126)(H,104,131)(H,105,132)(H,106,137)(H,107,130)(H,108,133)(H,109,136)(H,110,125)(H,111,134)(H,112,129)(H,113,127)(H,114,128)(H,115,124)(H,120,121)(H,122,123)(H,139,140)(H4,91,92,97)(H4,93,94,98)(H4,95,96,99)/t46-,51+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,67+,68+,69+,70+/m1/s1
InChI Key RNKJDHAVPKDCSA-KHBOZDSRSA-N
References
1. Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA. (2001)
[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.
Br J Pharmacol, 133 (3): 371-8. [PMID:11375253]
2. Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS et al.. (1999)
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
Nature, 400 (6741): 261-5. [PMID:10421367]
3. Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H et al.. (2001)
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Proc Natl Acad Sci USA, 98 (13): 7564-9. [PMID:11404457]
4. Suply T, Della Zuana O, Audinot V, Rodriguez M, Beauverger P, Duhault J, Canet E, Galizzi JP, Nahon JL, Levens N et al.. (2001)
SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
J Pharmacol Exp Ther, 299 (1): 137-46. [PMID:11561073]
5. Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, Hawes BE. (2001)
Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.
J Biol Chem, 276 (37): 34664-70. [PMID:11459838]