Synonyms: SBT-272 | SBT272
Compound class:
Peptide or derivative
Comment: Bevemipretide is a modified tripeptide (H-DArg-2,6-diMeTyr-Unk, from PubChem) that helps to stabilise the cardiolipin-rich inner mitochondrial membrane and promotes antioxidant, neuroprotective and mitochondria-protective effects in upper motor neurons (UMNs) [1].
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References |
1. Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D et al.. (2023)
SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. Neurobiol Dis, 178: 106022. [PMID:36716828] |