neuromedin U-8   Click here for help

GtoPdb Ligand ID: 1473

Abbreviated name: NmU-8
Synonyms: NMU-8 | porcine neuromedin U-8
Comment: Cleaved from porcine NMU-25
Species: Pig
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2D Structure
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Canonical SMILES CC(CC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)O)CC(=O)N)CCCN=C(N)N)CCCN=C(N)N)Cc1ccccc1)NC(=O)C(NC(=O)C(Cc1ccc(cc1)O)N)Cc1ccccc1)C
Isomeric SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O
InChI InChI=1S/C54H77N15O11/c1-31(2)26-39(66-49(76)40(28-32-12-5-3-6-13-32)65-45(72)36(55)27-34-19-21-35(70)22-20-34)47(74)67-41(29-33-14-7-4-8-15-33)48(75)64-38(17-10-24-62-54(59)60)51(78)69-25-11-18-43(69)50(77)63-37(16-9-23-61-53(57)58)46(73)68-42(52(79)80)30-44(56)71/h3-8,12-15,19-22,31,36-43,70H,9-11,16-18,23-30,55H2,1-2H3,(H2,56,71)(H,63,77)(H,64,75)(H,65,72)(H,66,76)(H,67,74)(H,68,73)(H,79,80)(H4,57,58,61)(H4,59,60,62)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
1. Aiyar N, Disa J, Foley JJ, Buckley PT, Wixted WE, Pullen M, Shabon U, Dul E, Szekeres PG, Elshourbagy NA et al.. (2004)
Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Pharmacology, 72 (1): 33-41. [PMID:15292653]
2. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams Jr DL, Feighner SD, Nunes CN et al.. (2000)
Identification of receptors for neuromedin U and its role in feeding.
Nature, 406 (6791): 70-4. [PMID:10894543]
3. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS et al.. (2000)
Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
J Biol Chem, 275 (42): 32452-9. [PMID:10899166]