UDP N-acetyl-glucosamine

Ligand id: 1779

Name: UDP N-acetyl-glucosamine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 18
Hydrogen bond donors 9
Rotatable bonds 11
Topological polar surface area 325.48
Molecular weight 607.08
XLogP -5.21
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Ashikov A, Routier F, Fuhlrott J, Helmus Y, Wild M, Gerardy-Schahn R, Bakker H. (2005)
The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.
J. Biol. Chem., 280 (29): 27230-5. [PMID:15911612]
2. Freeman K, Tsui P, Moore D, Emson PC, Vawter L, Naheed S, Lane P, Bawagan H, Herrity N, Murphy K et al.. (2001)
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Genomics, 78 (3): 124-8. [PMID:11735218]
3. Fricks IP, Carter RL, Lazarowski ER, Harden TK. (2009)
Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.
J. Pharmacol. Exp. Ther., 330 (1): 162-8. [PMID:19339661]
4. Ishida N, Miura N, Yoshioka S, Kawakita M. (1996)
Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.
J. Biochem., 120 (6): 1074-8. [PMID:9010752]
5. Ishida N, Yoshioka S, Chiba Y, Takeuchi M, Kawakita M. (1999)
Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter.
J. Biochem., 126 (1): 68-77. [PMID:10393322]
6. Miura N, Ishida N, Hoshino M, Yamauchi M, Hara T, Ayusawa D, Kawakita M. (1996)
Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.
J. Biochem., 120 (2): 236-41. [PMID:8889805]