INSL3   Click here for help

GtoPdb Ligand ID: 1995

Synonyms: insulin-like peptide 3
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Bathgate RA, Halls ML, van der Westhuizen ET, Callander GE, Kocan M, Summers RJ. (2013)
Relaxin family peptides and their receptors.
Physiol Rev, 93 (1): 405-80. [PMID:23303914]
2. Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ. (2005)
Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).
J Pharmacol Exp Ther, 313 (2): 677-87. [PMID:15649866]
3. Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA. (2008)
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.
J Biol Chem, 283 (25): 17287-97. [PMID:18434306]
4. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ. (2002)
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.
J Biol Chem, 277 (35): 31283-6. [PMID:12114498]
5. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ. (2003)
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.
J Biol Chem, 278 (10): 7855-62. [PMID:12506116]